Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 July 1971:
Vol. 173. no. 3994, pp. 336 - 338
DOI: 10.1126/science.173.3994.336
Prev | Table of Contents | Next

Articles

[3H]Adenosine Triphosphate: Release during Stimulation of Enteric Nerves

Che Su 1, John A. Bevan 1, and Geoffrey Burnstock 1

1 Department of Pharmacology, University of California School of Medicine, Los Angeles 90024

The isolated taenia coli of the guinea pig takes up tritiated adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, in preference to tritiated inosine and adenine. After uptake, [3H]adenosine is converted and retained primarily as [3H]adenosine triphosphate. Tritium is released from taenia coli treated with [3H]adenosine upon activation of the nonadrenergic inhibitory nerves. These results are consistent with the previous evidence that adenosine triphosphate may be the transmitter from the nerves.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Historical Perspective on the Discovery of Adenyl Purines.
D. J. Cheek, J. M. McHugh, J. Blood-Siegfried, J. F. McFetridge, and B. S. Turner (2000)
Biol Res Nurs 1, 265-275
   Abstract »    PDF »
Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons.
J. MacDonald, J. Barker, S. Paul, P. Marangos, and P Skolnick (1979)
Science 205, 715-717
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)