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Science 23 July 1971:
Vol. 173. no. 3994, pp. 334 - 336
DOI: 10.1126/science.173.3994.334
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Articles

Genetic Aspects of Increase in Rat Liver Aldehyde Dehydrogenase Induced by Phenobarbital

Richard A. Deitrich 1

1 Department of Pharmacology, University of Colorado Medical Center, Denver 80220

In the supernatant fraction of homogenized rat liver, the activity of aldehyde dehydrogenase that is dependent on nicotinamide adenine dinucleotide (E.C. 1.2.1.3) is increased up to tenfold after administration of phenobarbital for 3 days. The effect is genetically controlled and is inherited as an autosomal dominant characteristic. The mechanism is apparently unrelated to other druginduced increases in enzyme activity such as that which occurs in the hepatic microsomal systems for drug metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tissue Distribution, Ontogeny, and Regulation of Aldehyde Dehydrogenase (Aldh) Enzymes mRNA by Prototypical Microsomal Enzyme Inducers in Mice.
Y. Alnouti and C. D. Klaassen (2008)
Toxicol. Sci. 101, 51-64
   Abstract »    Full Text »    PDF »
Assessment of Hepatocytes and Liver Slices as in Vitro Test Systems to Predict in Vivo Gene Expression.
B. A. Jessen, J. S. Mullins, A. de Peyster, and G. J. Stevens (2003)
Toxicol. Sci. 75, 208-222
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)