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Science 23 July 1971:
Vol. 173. no. 3994, pp. 330 - 332
DOI: 10.1126/science.173.3994.330
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Articles

Cerebrospinal Fluid Production by the Choroid Plexus and Brain

Thomas H. Milhorat 1, Mary K. Hammock 2, Joseph D. Fenstermacher 3, David P. Rall 3, and Victor A. Levin 4

1 Office of the Scientific Director, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland; Department of Neurosurgery, Children's Hospital, Washington, D.C.
2 Office of the Scientific Director, National Institute of Neurological Diseases and Stroke; Department of Neurosurgery, George Washington University, Washington, D.C.
3 Office of Associate Scientific Director of Experimental Therapeutics, National Cancer Institute, Bethesda, Maryland
4 Department of Neurology, Massachusetts General Hospital, Boston

The production of cerebrospinal fluid and the transport of 24Na from the blood to the cerebrospinal fluid were studied simultaneously in normal and choroid plexectomized rhesus monkeys. Choroid plexectomy reduced the production of cerebrospinal fluid by an average of 33 to 40 percent and the rate of appearance of 24Na in the cerebrospinal fluid and its final concentration were proportionately reduced. In both normal and plexectomized animals, 24Na levels were found to be markedly greater in the gray matter surrounding the ventricles and in the gray matter bordering the subarachnoid space. That sodium exchanges in these two general areas of the brain may be linked to the formation of the cerebrospinal fluid is discussed here.


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