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Science 16 July 1971:
Vol. 173. no. 3993, pp. 251 - 252
DOI: 10.1126/science.173.3993.251
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Articles

Erythrocytes: Pits and Vacuoles as Seen with Transmission and Scanning Electron Microscopy

Bertram Schnitzer 1, Doanld L. Rucknagel 1, Herbert H. Spencer 1, and Masamichi Aikawa 2

1 Departments of Pathology, Human Genetics, and Internal Medicine, University of Michigan, Ann Arbor 48104; Veterans Administration Hospital, Ann Arbor, Michigan 48105
2 Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106

Vacuoles containing inclusions were observed by transmission electron microscopy in erythrocytes of a splenectomized patient with hemoglobin Ann Arbor. The membranes of these vacuoles became fused with the surface membrane of the red cell, thus opening the vacuoles and exposing their contents to the outside. These vacuoles when they have become thus attached to the cell membrane of the erythrocyte are responsible for the pits observed with scanning electron microscopy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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B. J. Angus, K. Chotivanich, R. Udomsangpetch, and N. J. White (1997)
Blood 90, 2037-2040
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RBC Surface Pits in the Sickle Hemoglobinopathies.
R. H. Sills and F. A. Oski (1979)
Arch Pediatr Adolesc Med 133, 526-527
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Biosynthesis of Hemoglobin Ann Arbor: Evidence for Catabolic and Feedback Regulation.
J. G. Adams III, W. P. Winter, D. L. Rucknagel, and H. H. Spencer (1972)
Science 176, 1427-1429
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