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Science 16 July 1971:
Vol. 173. no. 3993, pp. 247 - 249
DOI: 10.1126/science.173.3993.247
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Articles

Nuclear Localization of Histamine in Neonatal Rat Brain

Anne B. Young 1, Candace D. Pert 1, David G. Brown 1, Kenneth M. Taylor 1, and Solomon H. Snyder 1

1 Departments of Pharmacology and Experimental Therapeutics, Psychiatry; Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gastric Histamine Metabolism After Acute Pyloric Ligation in the Shay Rat.
C. D. McAlpin, T. C. Moore, and C. A. E. Lemmi (1974)
Arch Surg 109, 65-67
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Science. ISSN 0036-8075 (print), 1095-9203 (online)