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Science 16 July 1971:
Vol. 173. no. 3993, pp. 239 - 240
DOI: 10.1126/science.173.3993.239
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Articles

Glycerinated Muscle Fibers: Relation between Isometric Tension and Adenosine Triphosphate Hydrolysis

W. J. Bowen 1 and L. Mandelkern 1

1 National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014; Department of Chemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee 32306

The isometric tension of glycerinated muscle fibers and the adenosine triphosphatase activity of homogenates were determined as a function of the concentration of adenosine triphosphate without the addition of divalent cations. These two phenomena are not parallel; large tensions can be developed with negligible hydrolysis of adenosine triphosphate. It is concluded that the large negative free energy change of the hydrolysis is not required for shortening or development of tension.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)