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Science 2 July 1971:
Vol. 173. no. 3991, pp. 64 - 65
DOI: 10.1126/science.173.3991.64
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Articles

Angiotensin-Forming Enzyme in Brain Tissue

Detlev Ganten 1, James L. Minnich 1, Pierre Grenger 1, Karl Hayduk 1, Hans Michael Brecht 1, André Barbeau 1, Roger Boucher 1, and Jacques Genest 1

1 Clinical Research Intstituite of Montreal, 110 Pine Avenue West, Montreal 130, Quebec

A renin-like enzyme is present in brain tissue and is independent of kidney and plasma renin. In the presence of homologous substrate it forms angiotensin. Administration of aldosterone significantly decreases this angiotensinforming enzyme activity, while administration of progesterone markedly enhances it.


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