Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 25 June 1971:
Vol. 172. no. 3990, pp. 1355 - 1357
DOI: 10.1126/science.172.3990.1355
Prev | Table of Contents | Next

Articles

Rubidium and Lithium: Opposite Effects on Amine-Mediated Excitement

Bernard J. Carroll 1 and Peter T. Sharp 1

1 Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Victoria, 3050, Australia

In mice the activation caused by morphine was antagonized by previous treatment with lithium and was potentiated by previous treatment with rubidium. Other antimanic drugs antagonized the morphine activation as well. The effect of rubidium was similar to that of the antidepressant drugs imipramine and pargyline. Rubidium may merit clinical evaluation as an antidepressant agent in man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Parasympathetic Suppression of Manic Symptoms by Physostigmine.
D. S. Janowsky, M. K. EI-Yousef, J. M. Davis, and H. J. Sekerke (1973)
Arch Gen Psychiatry 28, 542-547
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)