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Science 25 June 1971:
Vol. 172. no. 3990, pp. 1353 - 1355
DOI: 10.1126/science.172.3990.1353
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Articles

Heterogeneity of Murine Leukemia Virus in vitro DNA; Detection of Viral DNA in Mammalian Cells

Lawrence D. Gelb 1, Stuart A. Aaronson 2, and Malcolm A. Martin 3

1 Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014
2 Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014
3 Laboratory of Biology of Viruses

Kinetic analysis of the reassociation of DNA synthesized in vitro by a murine leukemia virus DNA polymerase revealed two classes of double-stranded product representative of 25 and 100 percent of viral genetic information. The DNA product representing the smaller portion of the viral genome comprised 85 percent of the double-stranded DNA generated in vitro and was extensively duplicated in the genomes of both normal cells and cells containing RNA tumor virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Qualitative and Quantitative Studies of AKR-type Murine Leukemia Virus Sequences in Mouse DNA.
S. K. Chattopadhyay, D. R. Lowy, N. M. Teich, A. S. Levine, and W. P. Rowe (1974)
Cold Spring Harb Symp Quant Biol 39, 1085-1101
   Abstract »    PDF »
Rous Sarcoma Virus Nucleotide Sequences in Cellular DNA: Measurement by RNA-DNA Hybridization.
P. E. Neiman (1972)
Science 178, 750-753
   Abstract »    PDF »


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