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Science 25 June 1971:
Vol. 172. no. 3990, pp. 1348 - 1350
DOI: 10.1126/science.172.3990.1348
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Articles

Cooperative Control of Potassium Accumulation by Ouabain in Vascular Smooth Muscle

Jagdish Gulati 1 and Allan W. Jones 1

1 Departments of Biomedical Engineering and Physiology, Bockus Research Institute, University of Pennsylvania, Philadelphia 19146

The effects of ouabain on potassium accumulation were studied in the dog carotid artery. It was confirmed that vascular smooth muscle lost potassium in the presence of ouabain greater than 10-9 molar. This effect could be reversed by systematically increasing potassium in the external medium. The action of ouabain on ion accumulation was represented quantitatively with the application of a recent biophysical approach.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cooperative Critical Thermal Transition of potassium Accumulation in Smooth Muscle.
I. L. Reisin and J. Gulati (1972)
Science 176, 1137-1139
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)