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Science 25 June 1971:
Vol. 172. no. 3990, pp. 1345 - 1346
DOI: 10.1126/science.172.3990.1345
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Articles

Cell-Surface Changes after Infection with Oncogenic Viruses: Requirement for Synthesis of Host DNA

John R. Sheppard 1, Arnold J. Levine 1, and Max M. Burger 1

1 Department of Biochemical Sciences, Princeton University, Princeton, New Jersey 08540

The change in the surface structure of cultutred mammalian cells infected with oncogenic DNA viruses was similar to that described for the fully and permanently transformed cell surfaces. The course of appearance of this change was established. Synthesis of host DNA is required for expression of the surface change triggered by infection with the oncogenic virus.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)