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Science 25 June 1971:
Vol. 172. no. 3990, pp. 1339 - 1341
DOI: 10.1126/science.172.3990.1339
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Articles

Phospholipid—Calcium Phosphate Complex: Enhanced Calcium Migration in the Presence of Phosphate

John M. Cotmore 1, George Nichols Jr. 1, and Roy E. Wuthier 2

1 Harvard School of Dental Medicine and Cancer Research Institute, New England Deaconess Hospital, Boston, Massachusetts 02215
2 University of Vermont College of Medicine, Burlington 05401

In the presence of acidic phospholipids, inorganic phosphate greatly enhances the net migration of calcium ions from the aqueous phase to the organic phase, an effect that does not occur at less than the physiological pH. The calcium complex in the organic phase is shown by electron microscopy to consist of spherules, composed of stoichiometric amount of calcium, inorganic phosphate, and phospholipid. The demonstration of complex formation between calcium phosphate and acidic phospholipids adds Support to the concept that phospholipids are involved in biological mineralization.


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