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Science 18 June 1971:
Vol. 172. no. 3989, pp. 1257 - 1258
DOI: 10.1126/science.172.3989.1257
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Articles

Inhibition of Biogenic Amine Uptake by Hydrogen Peroxide: A Mechanism for Toxic Effects of 6-Hydroxydopamine

Richard Heikiila 1 and Gerald Cohen 1

1 Columbia University, College of Physicians & Surgeons, 640 West 168 Street, New York 10032

Hydrogen peroxide, dialuric acid, or 6-hydroxydopamine inhibited the uptake of dopamine, norepinephrine, and serotonin into rat brain synaptosomal preparations. The addition of catalase protected all systems, but catalase was only partially protective for 6-hydroxydopamine acting upon catecholamine uptake. The data show that 6-hydroxydopamine generates hydrogen peroxide and that hydrogen peroxide can damage the biogenic amine uptake systems. Part of the damage caused by the 6-hydroxydopamine that accumulates in the catecholamine nerve terminals in vivo may be attributed to the hydrogen peroxide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Selegiline as an Adjunct to Conventional Levodopa Therapy in Parkinson's Disease: Experience With This Type B Monoamine Oxidase Inhibitor in 200 Patients.
T. S. Elizan, M. D. Yahr, D. A. Moros, M. R. Mendoza, S. Pang, and C. A. Bodian (1989)
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Brain Peroxidase and Catalase in Parkinson Disease.
L. M. Ambani, M. H. Van Woert, and S. Murphy (1975)
Arch Neurol 32, 114-118
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Science. ISSN 0036-8075 (print), 1095-9203 (online)