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Science 18 June 1971:
Vol. 172. no. 3989, pp. 1245 - 1247
DOI: 10.1126/science.172.3989.1245
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Articles

Salicylate: Effect on Membrane Permeability of Molluscan Neurons

Jeffery L. Barker 1 and Herbert Levitan 1

1 Laboratory of Neurophysiology, National Institute of Meental Healtlh, Bethlesda, Maryland 20014

Identified cells in the buccal ganglion of the marine mollusk Navanax inermis were exposed to salicylate (1 to 30 millimoles per liter) for short periods. Salicylate increased the permneability to potassium and decreased the permeability to chloride in a reversible, dose-dependent manner, producing a concomitant increase in membrane potential and a decrease in membrane resistance. These events would reduce the output from, as well as the effectiveness of synaptic input to, a particular neuron.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diffusion of Weak Acids across Lipid Bilayer Membranes: Effects of Chemical Reactions in the Unstirred Layers.
J. Gutknecht and D. C. Tosteson (1973)
Science 182, 1258-1261
   Abstract »    PDF »
Membrane Permeability: Cation Selectivity Reversibly Altered by Salicylate.
H. Levitan and J. L. Barker (1972)
Science 178, 63-64
   Abstract »    PDF »
Salicylate: A Structure-Activity Study of its Effects on Membrane Permeability.
H. Levitan and J. L. Barker (1972)
Science 176, 1423-1425
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)