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Science 18 June 1971:
Vol. 172. no. 3989, pp. 1237 - 1238
DOI: 10.1126/science.172.3989.1237
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Articles

Adenosine 3', 5'-Monophosphate Increases Capacity for RNA Synthesis in Rat Liver Nuclei

Linda A. Dokas 1 and Lewis J. Kleinsmith 1

1 Department of Zoology, University of Michigan, Ann Arbor 48104

Liver nuclei isolated from rats injected with adenosine 3', 5'-monophosphate exhibit an increased capacity for RNA synthesis compared with nuclei from control animals. This effect, which is highly specific for the cyclic nucleotide. can be observed within 1 hour after injection in both unoperated and adrenalectomized rats. These findings suggest that induction of enzyme synthesis mediated by way of adenosine 3', 5'-monophosphate may be controlled, at least in part, at the level of gene transcription.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)