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Science 18 June 1971:
Vol. 172. no. 3989, pp. 1232 - 1234
DOI: 10.1126/science.172.3989.1232
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Articles

Vitamin D Metabolism: The Role of Kidney Tissue

R. Gray 1, I. Boylf 1, and H. F. Deluca 1

1 Departments of Biochemistry and Medicine, University of Wisconzsin, Madison 53706

The appearance of a polar metabolite of 25-hydroxychotecalciferol has been studied in the intestinal mucosas of nephrectomized rats and rats which have been made uremic by ureter ligation. In confirmation of previous work by Fraser and Kodicek, it was found that nephrectomy prevents the appearance of this metabolite in the intestine. On the other hand, equivalent amounts of the metabolite were found in uremic rats and in sham-operated controls, showing that the production of this metabolite is independent of the uremic state of the animals. In addition, it was shown that the metabolite produced in vitro by kidney homogenates is identical to that found in vivo in the intestine.


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Hypercalcemia and Elevated Calcitriol in a Maintenance Dialysis Patient With Tuberculosis.
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Vitamin D Metabolism and Function.
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Arch Intern Med 138, 836-847
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1,25-Dihydroxyvitamin D in biological fluids: a simplified and sensitive assay.
J. Eisman, A. Hamstra, B. Kream, and H. DeLuca (1976)
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Vitamin D Endocrinology.
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Ann Intern Med 85, 367-377
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Vitamin-D-Resistant Idiopathic Hypoparathyroidism: Acute Hypercalcemia During Acute Renal Failure.
B. S. Chertow, S. R. Plymate, and F. O. Becker (1974)
Arch Intern Med 133, 838-840
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Diphenylhydantoin: Effects on Calcium Metabolism in the Chick.
M. Villareale, L. V. Gould, R. H. Wasserman, A. Barr, R. T. Chiroff, and W. H. Bergstrom (1974)
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Vitamin D: A Reawakening.
P. A. Palmisano (1973)
JAMA 224, 1526-1527
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1agr-Hydroxy Derivative of Vitamin D3: A Highly Potent Analog of 1agr,25-Dihydroxyvitamin D3.
M. F. Holick, E J. Semmler, H. K. Schnoes, and H. F. Deluca (1973)
Science 180, 190-191
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5,6-Trans-25-Hydroxycholecalciferol: Vitamin D Analog Effective on Intestine of Anephric Rats.
M. F. Holick, M. Garabedian, and H. F. DeLuca (1972)
Science 176, 1247-1248
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1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D3 Active on Bone in Anephric Rats.
M. F. Holick, M. Garabedian, and H. F. DeLuca (1972)
Science 176, 1146-1147
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1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture.
L. G. Raisz, C. L. Trummel, M. F. Holick, and H. F. Deluca (1972)
Science 175, 768-769
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Strontium Induced Rickets: Metabolic Basis.
J. L. Omdahl and H. F. DeLuca (1971)
Science 174, 949-951
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