Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 June 1971:
Vol. 172. no. 3988, pp. 1148 - 1149
DOI: 10.1126/science.172.3988.1148
Prev | Table of Contents | Next

Articles

Transport of Nitrogen Mustard on the Transport-Carrier for Choline in L5178Y Lymphoblasts

Gerald J. Goldenberg 1, Candice L. Vanstone 1, and Ivan Bihler 1

1 Departments of Medicine and Pharmacology, University of Manitoba, and Manitoba Institute of Cell Biology, Winnipeg 3, Manitoba, Canada

The uptake of choline by L5178Y lymphoblasts occurs by a carrier mechanism and is an active process. Transport of nitrogen mustard and its hydrolyzed derivative is mediated by this same carrier. This finding is an example of drug transport by a carrier whose primary function is transport of a naturally occurring substrate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bifunctional Alkylating Agent-Induced p53 and Nonclassical Nuclear Factor {kappa}B Responses and Cell Death Are Altered by Caffeic Acid Phenethyl Ester: A Potential Role for Antioxidant/Electrophilic Response-Element Signaling.
G. D. Minsavage and J. F. Dillman III (2007)
J. Pharmacol. Exp. Ther. 321, 202-212
   Abstract »    Full Text »    PDF »
Efficient Protection of Human Bronchial Epithelial Cells against Sulfur and Nitrogen Mustard Cytotoxicity Using Drug Combinations.
S. Rappeneau, A. Baeza-Squiban, F. Marano, and J.-H. Calvet (2000)
Toxicol. Sci. 58, 153-160
   Abstract »    Full Text »    PDF »
Differential competition with cytotoxic agents: an approach to selectivity in cancer chemotherapy.
M Rabinowitz, Y Uehara, and D. Vistica (1979)
Science 206, 1085-1087
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)