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Science 4 June 1971:
Vol. 172. no. 3987, pp. 1058 - 1060
DOI: 10.1126/science.172.3987.1058
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Articles

Hycanthone: A Frameshift Mutagen

Philip E. Hartman 1, Kathryn Levine 1, Zlata Hartman 1, and Hillard Berger 1

1 Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218

Rapid spot-test screening of antischistosomal agents reveals that hycanthone is a potent frameshift mutagen while the closely related compound, miracil D, is nonmutagenic in Salmonella. Both hycanthone and miracil D are frameshift mutagens for T4 bacteriophage during growth in Escherichia coli.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens.
B. N. Ames, P. Sims, and P. L. Grover (1972)
Science 176, 47-49
   Abstract »    PDF »
Comparative Ability of Hycanthone and Miracil D to Interact with DNA.
E. Hirschberg and I. B. Weinstein (1971)
Science 174, 1147-1148
   PDF »
Hycanthone Resistance: Development in Schistosoma mansoni.
S. H. Rogers and E. Bueding (1971)
Science 172, 1057-1058
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)