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Science 4 June 1971:
Vol. 172. no. 3987, pp. 1057 - 1058
DOI: 10.1126/science.172.3987.1057
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Articles

Hycanthone Resistance: Development in Schistosoma mansoni

Steffen H. Rogers 1 and Ernest Bueding 1

1 Department of Pathobiology, School of Hygiene and Public Health, and Department of Pharmacology and Experimental Therapeutics, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205

Following the administration of relatively high doses of the antischistosomal drug hycanthone to mice and hamsters infected with Schistosoma mansoni, a number of the worms survived. After a period of 6 to 12 months these parasites resumed production of viable eggs that gave rise to schistosomes that proved resistant to hycanthone and to two other related antischistosomal compounds. This drug resistance has remained stable for three subsequent generations of worms.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)