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Science 4 June 1971:
Vol. 172. no. 3987, pp. 1037 - 1039
DOI: 10.1126/science.172.3987.1037
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Articles

Brain Histamine: Rapid Apparent Turnover Altered by Restraint and Cold Stress

Kenneth M. Taylor 1 and Solomon H. Snyder 1

1 Department of Pharmacology and Experimental Therapeutics and Department of Psychiatry and the Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Histamine content of rat brain was lowered quickly by inhibitors of histidine decarboxylase, suggesting that a portion of brain histamine turns over rapidly. Restraint and exposure to cold also reduced brain histamine levels and markedly augmented its formation in the hypothalamus.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)