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Science 21 May 1971:
Vol. 172. no. 3985, pp. 854 - 855
DOI: 10.1126/science.172.3985.854
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Articles

Cross-Linked Transfer RNA Functions in All Steps of the Translation Process

LaJean Chaffin 1, Daniel R. Omilianowski 1, and Robert M. Bock 1

1 Laboratory of Molecular Biology and Department of Biochemistry, University of Wisconsin, Madison 53706

A specific photochemical reaction between 4-thiouridine and cytosine cross-links two arms of transfer RNA. This cross-link, introduced into phenylalanine transfer RNA and arginine transfer RNA, limits the conformational freedom of the molecule. Both modified transfer RNA's are capable of functioning in all steps of protein synthesis with this restraint on allowable conformations.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)