Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 May 1971:
Vol. 172. no. 3985, pp. 851 - 854
DOI: 10.1126/science.172.3985.851
Prev | Table of Contents | Next

Articles

DNA Polymerase Required for Rapid Repair of X-ray—Induced DNA Strand Breaks in vivo

Christopher D. Town 1, Kendric C. Smith 1, and Henry S. Kaplan 1

1 Department of Radiology, Stanford University School of Medicine, Stanford, California 94305

A much higher yield of DNA single-strand breaks was obtained in the DNA polymerase-deficient mutant Escherichia coli K-12 pol A1 after a given dose of x-rays than had been found before in Escherichia coli. The increased yield of single-strand breaks was due to the absence of a rapid repair system, which had not been described in Escherichia coli K-12. This absence probably accounts for the x-ray sensitivity of the pol A1 mutant. The rapid repair system can be reversibly inhibited in pol+ cells.

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)