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Science 14 May 1971:
Vol. 172. no. 3984, pp. 736 - 738
DOI: 10.1126/science.172.3984.736
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Articles

L-Glutaminase: Suppression of Lymphocyte Blastogenic Responses in vitro

Evan M. Hersh 1

1 Department of Developmental Therapeutics, University of Texas M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston 77025

Continuous exposure to 0.1 international unit or more of Escherichia coli L-glutaminase inhibited responses of human lymphocytes to phytohemagglutinin, streptolysin O, and allogeneic leukocytes. Inhibition was completety reversed by removing the enzyme from the culture or adding L-glutamine but not L-asparagine. Cytoxicity did not occur. L-Glutaminase should be immunosuppressive in vivo.


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