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Science 14 May 1971:
Vol. 172. no. 3984, pp. 729 - 731
DOI: 10.1126/science.172.3984.729
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Articles

Tumor hnmunity: Tumor Suppression in vivo Initiated by Soluble Products of Specifically Stimulated Lymphocytes

Irwin D. Bernstein 1, Daniel E. Thor 1, Berton Zbar 1, and Herbert J. Rapp 1

1 Biology Branch, National Cancer Institute and Laboratory of Virology and Rickettsiology, Division of Biologics Standards, Bethesda, Maryland 20014

Supernatant fluids of specifically stimulated lymphocyte cultures were purified. Fractions containing migration inhibition factor when injected intra-dermally into strain-2 guinea pigs produced a reaction similar in appearance to delayed cutaneous hypersensitivity. There was an accumulation of mononuclear cells at the injection sites and the growth of syngeneic tumor grafts at the sites was suppressed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)