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Science 14 May 1971:
Vol. 172. no. 3984, pp. 725 - 727
DOI: 10.1126/science.172.3984.725
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Articles

Molecular Conformation of Dihydrouridine: Puckered Base Nucleoside of Transfer RNA

M. Sundaralingam 1, S. T. Rao 1, and J. Abola 1

1 Crystallography Laboratory, Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706

The crystal structure of dihydrouridine hemihydrate has been determined by x-ray diffraction. Crystals of dihydrouridine contain two independent molecules in the asymmetric unit and a molecule of water. The x-ray structure determination has shown that the conformations of both molecules differ in important respects in the saturated base and the ribose. The molecular conformation of dihydrouridine has, for the first time, provided structural evidence that the rare nucleoside can proinote "loop" formation in the sugar-phosphate chain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Posttranscriptional Modification of the Central Loop of Domain V in Escherichia coli 23 S Ribosomal RNA.
J. A. Kowalak, E. Bruenger, and J. A. McCloskey (1995)
J. Biol. Chem. 270, 17758-17764
   Abstract »    Full Text »    PDF »
Crystal Structure of a Naturally Occurring Dinucleoside Monophosphate: Uridylyl (3',5') Adenosine Hemihydrate.
J. Rubin, T. Brennan, and M. Sundaralingam (1971)
Science 174, 1020-1022
   Abstract »    PDF »


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