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Science 7 May 1971:
Vol. 172. no. 3983, pp. 583 - 585
DOI: 10.1126/science.172.3983.583
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Articles

Cholinergic Sensitivity: Normal Variability as a Function of Stimulus Background

Laszlo Z. Bito 1, M. Joan Dawson 1, and Ljerka Petrinovi\l=c`\ 1

1 Ophthalmology Research, Columbia University School of Medicine, New York 10032

The sensitivity of the normally innervated iris sphincter to its neuro-transmitter, acetylchloline, and to relatd agents varies inversely with the preexisting physiological stimulus background, that is, the environmental light intnsity. This normal variability suggests the existence of a negative feedback mechahnism whereby sensitivity of the effector cell is modutlated by a product of neuronal activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Age-Related Loss of Morphologic Responses to Pilocarpine in Rhesus Monkey Ciliary Muscle.
E. Lutjen-Drecoll, E. Tamm, and P. L. Kaufman (1988)
Arch Ophthalmol 106, 1591-1598
   Abstract »    PDF »
Pineal beta-Adrenergic Receptor: Diurnal Variation in Sensitivity.
J. A. Romero and J. Axelrod (1974)
Science 184, 1091-1092
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)