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Science 7 May 1971:
Vol. 172. no. 3983, pp. 570 - 572
DOI: 10.1126/science.172.3983.570
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Articles

Maintenance of Resting Potential in Anoxic Guinea Pig Ventricular Muscle: Electrogenic Sodium Pumping

T. F. McDonald 1 and Don P. MacLeod 1

1 Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia

Anoxic ventricular muscle maintained a normal resting potenitial despite a large loss of potassium. The resting potential was separated into two components: one that depended on the potassium distribution, and one that depended on the activity of an electrogenic sodium pump.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)