Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 April 1971:
Vol. 172. no. 3982, pp. 498 - 499
DOI: 10.1126/science.172.3982.498
Prev | Table of Contents | Next

Articles

Norepinephrine Biosynthesis Inhibition: Effects on Memory in Mice

Clark T. Randt 1, David Quartermain 1, Menek Goldstein 2, and Berta Anagnoste 2

1 Department of Neurology, School of Medicine, New York University, New York 10016
2 Department of Psychiatry, School of Medicine, New York University

Diethyldithiocarbamate, a dopamine beta hydroxylase inhibitor, decreases biosynthesis of norepinephrine in the brain. The effects of this inhibitor coincide with alterations in memory as demonstrated in single-trial passive avoidance in C57BL/6J mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nutritional Status, Cognition, and Survival: A NEW ROLE FOR LEPTIN AND AMP KINASE.
Y. Dagon, Y. Avraham, I. Magen, A. Gertler, T. Ben-Hur, and E. M. Berry (2005)
J. Biol. Chem. 280, 42142-42148
   Abstract »    Full Text »    PDF »
Clonidine Treatment of Alzheimer's Disease.
E. Mohr, J. Schlegel, G. Fabbrini, J. Williams, M. M. Mouradian, U. M. Mann, J. J. Claus, P. Fedio, and T. N. Chase (1989)
Arch Neurol 46, 376-378
   Abstract »    PDF »
Mental symptoms in Huntington's disease and a possible primary aminergic neuron lesion.
J. Mann, M Stanley, S Gershon, and M Rossor (1980)
Science 210, 1369-1371
   Abstract »    PDF »
Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity.
W. McEntee and R. Mair (1978)
Science 202, 905-907
   Abstract »    PDF »
Retrograde amnesia produced by several treatments: evidence for a common neurobiological mechanism.
P. Gold and D. Sternberg (1978)
Science 201, 367-369
   Abstract »    PDF »
Memory formation: evidence for a specific neurochemical system in the amygdala.
M Gallagher, B. Kapp, R. Musty, and P. Driscoll (1977)
Science 198, 423-425
   Abstract »    PDF »
Facilitation of the Long-Term Store of Memory with Strychnine.
H. P. Alpern and J. C. Crabbe (1972)
Science 177, 722-724
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)