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Science 23 April 1971:
Vol. 172. no. 3981, pp. 387 - 388
DOI: 10.1126/science.172.3981.387
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Articles

Striated Muscle Fibers: Facilitation of Contraction at Short Lengths by Caffeine

Reinhardt Rüdel 1 and Stuart R. Taylor 1

1 Department of Physiology, University College London, London, W.C. 1, England, and Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn 11203

One of the factors evidently responsible for decreasing the force of muscle contraction with shortening is inactivation of the myofibrils in the core of a muscle fiber. Caffeine antagonizes this inactivation and, correspondingly, changes the length-force relationship at short muscle lengths.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Skeletal muscle: length-dependent effects of potentiating agents.
Lopez JR, L. Wanek, and Taylor SR (1981)
Science 214, 79-82
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Muscle activation: effects of small length changes on calcium release in single fibers.
E. Ridgeway and A. Gordon (1975)
Science 189, 881-884
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Length-Force Relation of Calcium Activated Muscle Fibers.
M. Schoenberg and R. J. Podolsky (1972)
Science 176, 52-54
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Science. ISSN 0036-8075 (print), 1095-9203 (online)