Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 April 1971:
Vol. 172. no. 3981, pp. 382 - 383
DOI: 10.1126/science.172.3981.382
Prev | Table of Contents | Next

Articles

Immunoglobulin Production by Human Lymphocytoid Lines and Clones: Absence of Genic Exclusion

Arthur D. Bloom 1, Kyoo W. Choi 1, and Barbara J. Lamb 1

1 Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48104

Immunoglobulin production was studied in established lines of normal human lymphocytes. Three lines which produced both immunoglobulin G and immunoglobulin M were cloned. Among the 25 immunoglobulin-producing clones, 23 produced both classes of immunoglobulins. These findings suggest that the phenomenon of genic exclusion does not hold for immunoglobulin production in lymphocytoid cells in culture.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)