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Science 16 April 1971:
Vol. 172. no. 3980, pp. 288 - 290
DOI: 10.1126/science.172.3980.288
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Articles

Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal Reaction

Dora B. Goldstein 1 and Nandita Pal 1

1 Department of Pharmacology, Stanford University School of Medicine, Stanford, California 94305

Intoxicating blood levels of ethanol are maintained for several days in mice housed in an atmosphere of ethanol vapor. On removal from the alcohol, all the mice develop withdrawal signs. The signs can be graded to indicate the time course and intensity of the withdrawal reaction.


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