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Science 16 April 1971:
Vol. 172. no. 3980, pp. 271 - 273
DOI: 10.1126/science.172.3980.271
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Articles

Immunotherapy of Cancer: Regression of Tumors after Intralesional Injection of Living Mycobacterium bovis

Berton Zbar 1 and Tomiko Tanaka 1

1 Cellular Immunity Section, Biology Branch, National Cancer Institute, Bethesda, Maryland 20014

Injection of living Mycobacterium bovis (strain BCG) into established intradermal tumors caused tumor regression and prevented the development of metastases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Vitro and In Vivo Effects of CpG-Oligodeoxynucleotides (CpG-ODN) on Murine Transitional Cell Carcinoma and on the Native Murine Urinary Bladder Wall.
P. J. OLBERT, A. J. SCHRADER, C. SIMON, A. DALPKE, P. BARTH, R. HOFMANN, and A. HEGELE (2009)
Anticancer Res 29, 2067-2076
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Effects of Vitamin D3-Binding Protein-Derived Macrophage Activating Factor (GcMAF) on Angiogenesis.
S. Kanda, Y. Mochizuki, Y. Miyata, H. Kanetake, and N. Yamamoto (2002)
J Natl Cancer Inst 94, 1311-1319
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Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate.
C. McLaughlin, S. Schwartzman, B. Horner, G. Jones, J. Moffatt, J. Nestor Jr, and D Tegg (1980)
Science 208, 415-416
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Calmette-Guerin Bacillus Treatment of Experimental Conjunctival Malignant Melanoma.
J. Rutgard, G. A. Peyman, M. Frenkel, and S. Saks (1977)
Arch Ophthalmol 95, 2214-2217
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Systemic Infection Following BCG Therapy.
E. B. Rosenberg, S. P. Kanner, R. J. Schwartzman, and J. Colsky (1974)
Arch Intern Med 134, 769-770
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Suppression of Urethan-Induced Lung Adenomas in Mice Treated with Trehalose-6,6-Dimycolate (Cord Factor) and Living Bacillus Calmette Guerin.
A. Bekierkunst, I. S. Levij, E. Yarkoni, E. Vilkas, and E. Lederer (1971)
Science 174, 1240-1242
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Immunotherapy of Cancer: Immunospecific Rejection of Tumors in Recipients of Neuraminidase-Treated Tumor Cells Plus BCG.
R. L. Simmons and A. Rios (1971)
Science 174, 591-593
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Science. ISSN 0036-8075 (print), 1095-9203 (online)