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Science 9 April 1971:
Vol. 172. no. 3979, pp. 176 - 177
DOI: 10.1126/science.172.3979.176
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Articles

Interaction of Rheumatoid Factor with Infectious Herpes Simplex Virus-Antibody Complexes

Warren K. Ashe 1, Charles A. Daniels 1, George S. Scott 1, and Abner Louis Notkins 1

1 Virology Section, Laboratory of Microbiology, National Institute of Dental Research, Bethesda, Maryland

Rheumatoid factor, a human immunoglobulin of the IgM class, failed to attach to herpes simplex virus but did attach to infectious complexes composed of herpes simplex virus and antibody to herpes simplex virus. These newly formed complexes of infectious virus, antiviral antibody, and rheumatoid factor could be neutralized by complement or by antibody to human IgM. The ability of rheumatoid factor to enhance virus neutralization in the presence of complement represents a hitherto unrecognized biological role for rheumatoid factor.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)