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Science 2 April 1971:
Vol. 172. no. 3978, pp. 56 - 57
DOI: 10.1126/science.172.3978.56

Articles

Conductance Changes Produced by Acetylcholine in Lipidic Membranes Containing a Proteolipid from Electrophorus

Mario Parisi 1, Emilio Rivas 1, and E. De Robertis 1

1 Instituto de Anatomiacgra General y Embriologiacgra, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

Ultrathin lipidic membranes containing one ten-thousandth of a special proteolipid from electric organ of Electrophorus reacted to the addition of acetylcholine by a rapid and transient increase in conductance. Such a change was not induced by choline and is greatly reduced by a previous application of d-tubocurarine. These properties, resembling those from chemically excitable membranes, were not observed with another proteolipid from the same tissue.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)