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Science 19 March 1971:
Vol. 171. no. 3976, pp. 1169 - 1170
DOI: 10.1126/science.171.3976.1169
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Articles

Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain

D. L. Cheney 1, A. Goldstein 1, S. Algeri 2, and E. Costa 2

1 Department of Pharmacology, Stanford University, Stanford, California 94305
2 Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032

Serotonin turnover was measured in mouse brain by means of the conversion of radioactivity from labeled tryptophan into serotonin. Animals with a high degree of tolerance to and physical dependence on morphine did not differ from control mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Narcotic Tolerance and Dependence and Serotonin Turnover.
R. J. Hitzemann, I. K. Ho, H. H. Loh, D. L. Cheney, and E. Costa (1972)
Science 178, 645-647
   PDF »
Narcotic Drugs: Effects on the Serotonin Biosynthetic Systems of the Brain.
S. Knapp and A. J. Mandell (1972)
Science 177, 1209-1211
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)