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Science 19 March 1971:
Vol. 171. no. 3976, pp. 1165 - 1167
DOI: 10.1126/science.171.3976.1165
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Articles

Stimulation in vitro with Protein Carrier of Antibodies against a Hapten

Andrei Sulica 1, Rebeca Tarrab 1, and Michael Sela 1

1 Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel

Rabbits were immunized both with lysozyme and with dinitrophenylated bovine serum albumin. No antibodies against the dinitrophenyl hapten were produced when cell suspensions of their spleens were exposed in vitro to dinitro-phenyl-ovalbumin, whereas a positive response was obtained with dinitrophenyl-lysozyme. Moreover, when spleen cells from rabbits previously immunized with dinitrophenyl-bovine serum albumin were exposed in vitro to bovine serum albumin alone, they produced antibodies against the dinitrophenyl hapten.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunologic Mechanisms in the Prevention and Therapy of Cancer.
T. A. Fleisher and J. H. Kersey (1974)
Arch Pediatr Adolesc Med 128, 739-742
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Science. ISSN 0036-8075 (print), 1095-9203 (online)