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Science 19 March 1971:
Vol. 171. no. 3976, pp. 1156 - 1158
DOI: 10.1126/science.171.3976.1156
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Articles

Adenosine 3',5'-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission

Donald A. McAfee 1, Michel Schorderet 1, and Paul Greengard 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

Brief periods of stimulation of the preganglionic nerve fibers produced a severalfold increase in the content of adenosine 3',5'-monophosphate in superior cervical sympathetic ganglia, whereas postganglionic stimulation did not. These and other experiments indicated that the increased concentrations of adenosine 3'5'-monophosphate were closely associated with the process of synaptic transmission. This increase occurred primarily in postsynaptic cells.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)