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Science 19 March 1971:
Vol. 171. no. 3976, pp. 1153 - 1155
DOI: 10.1126/science.171.3976.1153
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Articles

Synaptic Transmission in the Crayfish: Increased Release of Transmitter Substance by Bacterial Endotoxin

I. Parnas 1, R. Reinhold 1, and J. Fine 1

1 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, and Harvard Surgical Unit, Boston City Hospital, Boston, Massachusetts 02118

Bacterial endotoxin increases the frequency of miniature excitatory postsynaptic potentials, decreases facilitation, and increases the evoked excitatory postsynaptic potential without changing membrane resistance. These data indicate that endotoxin acts on the presynaptic nerve terminal by increasing the amount of transmitter substance released in response to an applied stimulus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Corticosteroid Treatment of Major Trauma: Mechanisms Involved in Their Therapeutic Effect.
P. Woodruff, D. Caridis, P. Cuevas, S. Koizumi, and J. Fine (1973)
Arch Surg 107, 613-616
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Science. ISSN 0036-8075 (print), 1095-9203 (online)