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Science 19 March 1971:
Vol. 171. no. 3976, pp. 1147 - 1149
DOI: 10.1126/science.171.3976.1147
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Articles

Conformational Equilibria in Spin-Labeled Hemoglobin

Walter J. Deal 1, Susan G. Mohlman 1, and Marcia L. Sprang 1

1 Department of Chemistry, University of California, Riverside 92502

A component characteristic of deoxyhemoglobin appears in the paramagnetic resonance spectrum of spin-labeled oxyhemoglobin, and vice versa, under conditions of pH and ionic strength consistent with the interpretation that the spectrum is sensitive to the conformational equilibrium of the carboxy-terminal histidines. The oxygenation-induced change in the resonance spectrum is discussed in terms of shifts in this equilibrium.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)