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Science 12 March 1971:
Vol. 171. no. 3975, pp. 1017 - 1019
DOI: 10.1126/science.171.3975.1017
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Articles

Perinatal Undernutrition: Accumulation of Catecholamines in Rat Brain

William J. Shoemaker 1 and Richard J. Wurtman 1

1 Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139

Brains of rats undernourished from midgestation and killed at weaning contained 25 percent less norepinephrine than brains of adequately fed littermates. Perinatal undernutrition also suppressed the accumulation of brain dopamine. Paradoxically, the activity of tyrosine hydroxylase, the enzyme thought to be rate-limiting in catecholamine biosynthesis, was significantly increased in brains from undernourished animals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Perinatal undernutrition reduces alpha and beta adrenergic receptor binding in adult rat brain.
E. Keller, N. Munaro, and O. Orsingher (1982)
Science 215, 1269-1270
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Sparing of the brain in neonatal undernutrition: amino acid transport and incorporation into brain and muscle.
L. Freedman, S Samuels, I Fish, S. Schwartz, B Lange, M Katz, and L Morgano (1980)
Science 207, 902-904
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Nutritional and Environmental Interactions in the Behavioral Development of the Rat: Long-Term Effects.
D. A. Levitsky and R. H. Barnes (1972)
Science 176, 68-71
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Science. ISSN 0036-8075 (print), 1095-9203 (online)