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Science 5 March 1971:
Vol. 171. no. 3974, pp. 917 - 920
DOI: 10.1126/science.171.3974.917
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Articles

Age-Associated Changes in the DNA of Mouse Tissue

Gerald B. Price 1, S. P. Modak 2, and T. Makinodan 3

1 University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, Tennessee 37830
2 Department of Microbiology, Medical Center, University of Kentucky, Lexington 40506
3 Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

The template activity of DNA with calf thymus DNA polymerase has been studied in sections of fixed brain, liver, and heart tissues from young and senescent mice. The enzyme catalyzed greater incorporation of deoxyribonucleotide monophosphates into nuclei of old mouse neurons, astrocytes, Kupffer cells, and heart muscle fibers. The results are interpreted as the accumulation of DNA strand breaks with aging.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)