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Science 5 March 1971:
Vol. 171. no. 3974, pp. 913 - 915
DOI: 10.1126/science.171.3974.913
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Articles

Density Gradient Separation of Marrow Cells Restricted for Antibody Class

Harold C. Miller 1 and Gustavo Cudkowicz 1

1 Department of Pathology, School of Medicine, State University of New York at Buffalo, Buffalo 14214

Primitive cells of (C3H x C57BL/10)F1 mouse bone marrow, participating with thymocytes in immune responses to sheep erythrocytes, are already committed to the immunoglobulin M or immunoglobulin G antibody class. By equilibrium centrifugation in discontinuous gradients of bovine serum albumin, cells responsible for production of IgM immunocytes migrate to the denser regions, whereas those responsible for IgG immunocytes remain in the lower density regions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Density Gradient Separation of Marrow Precursor Cells Restricted for Antibody Specificity.
H. C. Miller and G. Cudkowicz (1971)
Science 173, 156-158
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Science. ISSN 0036-8075 (print), 1095-9203 (online)