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Science 5 March 1971:
Vol. 171. no. 3974, pp. 910 - 911
DOI: 10.1126/science.171.3974.910
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Articles

Ethacrynic Acid Effect on the Composition of Cochlear Fluids

Edward S. Cohn 1, Ellen H. Gordes 1, and Saul W. Brusilow 1

1 Division of Otolaryngology, Department of Surgery and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Ethacrynic acid, when administered to six dogs, caused a fall in the concentration of potassium in endolymph from 145 to 21 milliequivalents per liter and a rise in the concentration of sodium from 5.9 to 146 milliequivalents per liter. The composition of perilymph is unaffected. Perilymph and endolymph are slightly hypertonic as compared to plasma.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ototoxicity of Ethacrynic Acid in the Anuric Guinea Pig.
J. A. McCurdy Jr., J. G. McCormick, and J. A. Harrill (1974)
Arch Otolaryngol Head Neck Surg 100, 143-147
   Abstract »    PDF »
Effect of Ethacrynic Acid on Endolymphatic DC Potential.
J. M. Dilling, T. Nakashima, and J. B. Snow Jr. (1973)
Arch Otolaryngol Head Neck Surg 98, 183-186
   Abstract »    PDF »
Interaction of Kanamycin and Ethacrynic Acid: Severe Cochlear Damage in Guinea Pigs.
B. A. West, R. E. Brummett, and D. L. Himes (1973)
Arch Otolaryngol Head Neck Surg 98, 32-37
   Abstract »    PDF »
Ototoxicity of the Ethacrynic Acid.
J. Prazma, W. G. Thomas, N. D. Fischer, and M. J. Preslar (1972)
Arch Otolaryngol Head Neck Surg 95, 448-456
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)