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Science 19 February 1971:
Vol. 171. no. 3972, pp. 680 - 682
DOI: 10.1126/science.171.3972.680
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Articles

Chromatid Breakage: Cytosine Arabinoside-Induced Lesions Inhibited by Ultraviolet Irradiation

William F. Benedict 1 and Myron Karon 2

1 Birth Defects Institute, New York State Department of Health, Albany
2 Division of Hematology, Childrens Hospital of Los Angeles, Los Angeles, California 90027

Exposure to ultraviolet light can reduce the frequency of chromatid breaks induced by cytosine arabinoside in the DNA synthetic and post-DNA synthetic phases of the cell cycle. This effect can be correlated temporally with a decrease in the uptake of tritiated thymidine after ultraviolet treatment, implying that the genesis of such breakage is intimately related to DNA synthesis and that such synthesis is not confined to the DNA synthetic phase.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of a High-Throughput Human HepG2 Dual Luciferase Assay for Detection of Metabolically Activated Hepatotoxicants and Genotoxicants.
X. Liu, J. A. Kramer, Y. Hu, J. M. Schmidt, J. Jiang, and A. G. E. Wilson (2009)
International Journal of Toxicology 28, 162-176
   Abstract »    Full Text »    PDF »
Chromatid Breakage: Differential Effect of Inhibitors of DNA Synthesis during G2 Phase.
M. Karon and W. F. Benedict (1972)
Science 178, 62
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)