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Science 12 February 1971:
Vol. 171. no. 3971, pp. 577 - 579
DOI: 10.1126/science.171.3971.577
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Articles

Specialization of Rabbit Reticulocyte Transfer RNA Content for Hemoglobin Synthesis

David W. E. Smith 1 and Anne L. McNamara 1

1 Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

The amount of acceptance of each amino acid per absorbancy unit of rabbit reticulocyte transfer RNA was determined. The results were compared with the amino acid composition of rabbit hemoglobin and with a similar determination of the transfer RNA content of rabbit liver. The histidine and isoleucine transfer RNA content of reticulocytes is specialized for the synthesis of hemoglobin, in which histidine is unusually common and isoleucine unusually scarce compared to most proteins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Globin mRNA Sequences: Analysis of Base Pairing and Evolutionary Implications.
W. Salser (1978)
Cold Spring Harb Symp Quant Biol 42, 985-1002
   Abstract »    PDF »
Reticulocyte transfer RNA and hemoglobin synthesis.
M Litt (1976)
Science 193, 428-429
   PDF »
Reticulocyte transfer RNA and hemoglobin synthesis.
D. Smith (1975)
Science 190, 529-535
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Science. ISSN 0036-8075 (print), 1095-9203 (online)