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Science 12 February 1971:
Vol. 171. no. 3971, pp. 575 - 577
DOI: 10.1126/science.171.3971.575
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Articles

A Portal Blood Factor as the Humoral Agent in Liver Regeneration

Bernard Fisher 1, Patricia Szuch 1, Morton Levine 1, and Edwin R. Fisher 1

1 Departments of Surgery and Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl-3H]- thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted,partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.


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