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Science 5 February 1971:
Vol. 171. no. 3970, pp. 498 - 499
DOI: 10.1126/science.171.3970.498
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Articles

Allergic Encephalomyelitis: New Form Featuring Polymorphonuclear Leukocytes

Seymour Levine 1 and Richard Sowinski 1

1 Pathology Department, New York Medical College Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, New York 10017

The passive transfer of allergic encephalomyelitis can be produced in a single day. In work described, the procedure was made to coincide with a transient drug-induced deficiency of lymphocytes. As a result, the lesions of this autoimmune disease contained a predominance of polymorphonuclear leukocytes instead of the usual mononuclear cells. Not only is this a new histologic form of the disease, but the ready recognition of polymorphonuclears as reactive cells provides a powerful new tool for investigating the roles of immunologically specific effector cells and nonspecific reactive cells in production of tissue damage.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Case 37-1995- A 6-year-old boy with a rash, meningismus, and diplegia.
D.A. Hafler and E.T. Hedley-Whyte (1995)
N. Engl. J. Med. 333, 1485-1493
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Science. ISSN 0036-8075 (print), 1095-9203 (online)