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Science 29 January 1971:
Vol. 171. no. 3969, pp. 404 - 406
DOI: 10.1126/science.171.3969.404
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Articles

Synergy of Ethanol and a Natural Soporific—Gamma Hydroxybutyrate

E. R. McCabe 1, E. C. Layne 1, D. F. Sayler 1, N. Slusher 1, and S. P. Bessman 1

1 Department of Pharmacology, University of Southern California, 2025 Zonal Avenue, Los Angeles 90033

ggr-Hydroxybutyrate and ethanol, as well as ggr-butyrolactone and ethanol are potentiative with respect to duration of loss of the righting reflex (sleep time). The concentration of ethanol in the liver decreases from 30 to 90 minutes after rats are injected with ethanol, but there is no change when ethanol is injected with ggr-butyrolactone. In view of the fact that ggr-hydroxybutyrate is a natural intermediate in brain, the effects of ethanol on the central nervous system may be mediated through its interaction with ggr-butyrolactone.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)