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Science 29 January 1971:
Vol. 171. no. 3969, pp. 400 - 402
DOI: 10.1126/science.171.3969.400
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Articles

Cyclic Adenosine and Guanosine Monophosphates and Glucagon: Effect on Liver Membrane Potentials

Naomi Friedmann 1, Avril V. Somlyo 2, and Andrew P. Somlyo 3

1 Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia
2 Presbyterian-University of Pennsylvania Medical Center, Philadelphia
3 Departments of Pathology, University of Pennsylvania School of Medicine and Presbyterian-University of Pennsylvania Medical Center, 51 North 39 Street, Philadelphia 19104

Cyclic adenosine monophosphate, cyclic guanosine monophosphate, glucagon, and isoproterenol each hyperpolarized perfused rat liver cells. The hyperpolarization followed a time course similar to the stimulated increase in potassium efflux and was preceded by the increase in calcium efflux. The hyperpolarization induced by cyclic adenosine monophosphate was blocked by tetracaine. The similarity of the action of the cyclic nucleotides to that of glucagon supports the hypothesis that cyclic adenosine monophosphate is the secondary messenger mediating the action of glucagon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alterations in Hepatic Water and Electrolyte Balance in Sepsis.
M. G. Clemens, I. H. Chaudry, and A. E. Baue (1984)
Arch Surg 119, 44-48
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Potassium Ion Release and Enzyme Secretion: Adrenergic Regulation by agr-and beta-Receptors.
S. Batzri, Z. Selinger, and M. Schramm (1971)
Science 174, 1029-1031
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