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Science 29 January 1971:
Vol. 171. no. 3969, pp. 389 - 390
DOI: 10.1126/science.171.3969.389
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Articles

Aggregations of 35-Nanometer Particles Associated with Neuronal Cytopathic Changes in Natural Scrapie

A. Bignami 1 and H. B. Parry 2

1 Department of Pathology, Stanford Medical Center, Stanford, California 94305
2 Nuffield Institute for Medical Research, Oxford, OX3 9.DS, England

Neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. Membrane-bound accumulations of the 35-nm particles are fotnd in the cytoplasmic processes that project inside the vacuoles of the neuronal perikaryon. Such particles are present only in a small number of vacuolated neurons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles.
L. Manuelidis, Z.-X. Yu, N. Barquero, and B. Mullins (2007)
PNAS 104, 1965-1970
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Science. ISSN 0036-8075 (print), 1095-9203 (online)